Sexual activity is a potential risk for patients with cardiovascular disease. Therefore, the treatment of erectile dysfunction, including the use of cialis generic can not be performed in men with heart disease, in which sexual activity is inadvisable. Consider the potential risk of complications of sexual activity in patients with heart disease - heart attack in the last 90 days, unstable angina or angina during sex heart failure, NYHA class 2 or greater hypertension developed in recent six months, uncontrolled arrhythmias, hypotension (blood pressure <90/50 mm Hg of art.) or uncontrolled disease and stroke, moved in 6 months.
cialis generic should be used with caution in patients predisposed to priapism (such as sickle cell anemia, multiple myeloma or leukemia), or patients with anatomical deformation of the penis (such as angulation, fibrosis hole or Peyronie's disease). Delays in the treatment of priapism lead to damage penile tissue, resulting in a loss may occur in the long term potential. The safety and efficacy of a combination of cialis generic with other treatments for erectile dysfunction have not been studied. Therefore, the use of such combinations is not recommended.
cialis generic treatment in patients with moderate renal impairment (creatinine clearance 31-50 ml / min) were the most common side effects, such as back pain, compared with patients with mild renal impairment (creatinine clearance creatinine 51-80 ml / min) or healthy subjects. In patients with severe renal impairment (creatinine clearance 30 ml / min) Tadalafil has not been studied. cialis generic drug should be prescribed to patients with a creatinine clearance of 50 ml / min
Effects on ability to drive and use machines:
No special requirements.
The influence of other drugs cialis generic:
Tadalafil is mainly metabolized by CYP3A4. Selective inhibitor of CYP3A4, ketoconazole increases the area under the "time of concentration" curve to 107% and rifampicin reduced by 88%. Although specific interactions are examined, one can assume that the protease inhibitors ritonavir, saquinavir and inhibitors of CYP3A4 such as erythromycin and itraconazole increased activity of tadalafil.
Concomitant treatment with an antacid (magnesium hydroxide / aluminum hydroxide) and tadalafil reduced the rate of absorption of tadalafil without altering the AUC for tadalafil. Increasing the pH of the stomach due to nizatidine H2 receptor antagonists had no effect on the pharmacokinetics of tadalafil.
How cialis generic is combined with other medications? Needless to say, cialis generic affect the validity of certain drugs. Therefore, before cialis generic is best to consult your doctor. Safely be combined cialis generic receiving the vitamins, minerals and dietary supplements (food supplements). Do not use cialis generic in combination with drugs that enhance erections.