Vardenafil material properties
Selective inhibitor of phosphodiesterase type 5 (PDE5).
Vardenafil hydrochloride - almost colorless solid having a molecular weight of 579.1, the water solubility, 0.11 mg / ml
To improve erectile function - mechanism of action.
Installation - on hemodynamic process of relaxation of smooth muscles of the corpora cavernosa and its associated arterioles is based. To sexual stimulation of vascular endothelial cells of the hollow body nitric oxide, which activate the enzyme guanylate cyclase, which in an increased cGMP in the synthesis of smooth muscle cells in the corpus cavernosum. The accumulation of cGMP leads to relaxation of smooth muscles and the spans of the corpora cavernosa, which increase blood flow to the penis and an erection. Tissue levels of cGMP is regulated by the rate of both synthesis and degradation by phosphodiesterases. Is dominated in the hollow body by cGMP phosphodiesterase type 5, so that the inhibition of PDE5 leads to an increase of cGMP, and promote an erection.
Because sexual stimulation is needed in the process, causing the local release of nitric oxide inhibition of PDE5 no effect in the absence of stimulation lead.
Have shown in vitro that the activity of levitra 10mg on PDE5 than other known isoforms of phosphodiesterase (> 15 compared FDE6> 130 - FDE1,> 300 - FDE11,> 1000 - FDE2, 3, 4, 7, 8, 9 and 10). buy levitra online generic cheap
At the start of treatment is recommended in the 10 mg. Is within if needed, for about 25-60 minutes before sexual activity. In addition to this vardenfil can be taken any time during the period of 4-5 hours to 25 minutes before intercourse. The maximum recommended frequency of application - 1 time / day.
levitra 10mg can be taken with meals. Effective treatment requires a sufficient level of sexual stimulation.
After the efficacy and safety of the treatment dose can be increased to 20 mg or decreased to 5 mg / day.
The maximum recommended dose is 20 mg 1 time / day.
In older patients, a dose adjustment is required.
In patients with moderate hepatic clearance of levitra 10mg is reduced so that the initial dose is 5 mg / day. In the future, increased mg depending on efficacy and tolerability of the dose to 10 mg and 20.
Of the central and peripheral nervous system: headache, dizziness, and in rare cases - increased muscle tone.
Since the cardiovascular system: the redness of the face as possible, just rare - high blood pressure, lowering blood pressure.
A part of the digestive system - indigestion, nausea.
The respiratory system: nasal congestion.
Dermatologic reactions: seldom - sensitivity to light.
A part of the reproductive system: seldom - priapism.